Logarithm of Odds (LOD)

Date:
1957-1973
Reference:
UGC 155/3/6
Part of:
Papers of Dr James Harrison Renwick, 1926-1994, geneticist, University of Glasgow, Scotland
  • Archives and manuscripts

About this work

Description

The Wellcome Library does not hold a digitised copy of all items in this series as part of Codebreakers: Makers of Modern Genetics. Items restricted in accordance with Data Protection legislation have not been digitised. Items not digitised may be viewed in the searchroom at Archive Services, University of Glasgow. Please visit the Glasgow University Archive Services website or see the complete catalogue for full details.

Publication/Creation

1957-1973

Physical description

1 box, 14 small ring binders, 38 folders

Arrangement

Arranged in original order of Renwick's boxfiles.

Biographical note

The Logarithm of Odds (LOD) score method for testing linkage was first proposed by Dr Newton Eniss Morton in 1955 although the underlying principles were previously set out by Professor Cedric Austen Bardell Smith. It is a statistical measure of the likelihood that two genetic markers occur together on the same chromosome and are inherited as a single unit of DNA. The calculation of LODs requires generational pedigree analysis, with higher LODs reflecting greater probability of linkage. A score of greater than 3 is generally taken as evidence for linkage.

In 1955 Renwick and Dr Sylvia Dorothy Lawler published a series of family trees demonstrating linkage between the ABO blood groups and the Nail-Patella Syndrome. The first calculations had to be done by hand. Renwick was a pioneer in devising computer programs for calculating LODs. In 1961 he and Dr Jane Schulze wrote a computer program for detailed analysis of pedigrees and calculation of points on a likelihood ratio curve.

Terms of use

The material is available in the Rare Materials Room subject to the usual conditions of access.Some files have access restrictions which are explained in the item-level catalogue records.

Location of duplicates

A digitised copy is held by the Wellcome Library as part of Codebreakers: Makers of Modern Genetics. Material restricted in accordance with Data Protection legislation has not been digitised.

Where to find it

Location of original

The original material is held at Glasgow University Archive Services. This catalogue is held by the Wellcome Library as part of Codebreakers: Makers of Modern Genetics.

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